The PIAS1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PIAS1. This antibody recognizes Human antigen. The PIAS1 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation By similarity.Bin Liu, Mol. Cell. Biol., Feb 2005; 25: 1113 - 1123. Hansol Lee, Genes & Dev., Apr 2006; 20: 784 - 794. Tamar Megidish, J. Biol. Chem., Mar 2002; 277: 8255 - 8259. Keiko Kawai-Kowase, Mol. Cell. Biol., Sep 2005; 25: 8009 - 8023